BĀKUCĪ – Psoralia corylifolia

 

Bākucī – Psoralia corylifolia

ParyAya (Synonymns in Ayurveda) :-
बाकुचीbākucī
अवल्गुज avalguja
सोमराजी – somarājī
सुपर्णिका – suparṇikā
शशिलेखा – śaśilekhā
चन्द्रलेखा – candralekhā
कृष्णफला – kṛṣṇaphalā
सोमा – somā
पूतिफल – pūtiphala
सोमवल्ली – somavallī
कालमेषी – kālameṣī

Scientific Name :- Psoralia corylifolia

Vernacular Names :- English : Psoraleae Fruit / हिन्दी : बायची / गुजराती : बांवची / தமிழ்: கார்போக அரிசி / ಕನ್ನಡ :- ಬಾವಂಚಿ ; ಬಾವಚಿಗೆ / മലയാളം: കര്കൊകില്, കര്കൊകിലരി, കൌര്കൊലരി തെലുങ്ക്: ബവന്ഛലു


bAkucI seed

Classifical References:-

    बाकुची मधुरा तिक्ता हिमा कटुपाका रासायनी |
    विष्टंभहृत् हिमा रुच्या सारा श्लेष्म अस्रपित्तनुत् ||
    रूक्षा हृद्या श्वास कुष्ठ प्रमेह ज्वर कृमिप्रणुत् |
    तत्फलं पित्तलं, कुष्ठकफानिलहरं कटु ||
    केष्यं त्वच्यं वमी श्वास शोथ पान्दुनुत् | भाव प्रकाश ||Transliteration:-
    bākucī madhurā tiktā himā kaṭupākā rāsāyanī |
    viṣṭaṃbhahṛt himā rucyā sārā śleṣma asrapittanut ||
    rūkṣā hṛdyā śvāsa kuṣṭha prameha jvara kṛmipraṇut |
    tatphalaṃ pittalaṃ, kuṣṭhakaphānilaharaṃ kaṭu ||
    keṣyaṃ tvacyaṃ vamī śvāsa śotha pāndunut | bhāva prakāśa ||
    By taste bAkucI is sweetish (primary taste); bitter (secondary taste).
    Post digestion vipAka of it is pungent (kaTu).
    The potency of psoralia as per BhAva PrakAsha is hot.
    DoShic Action:- Being tikta in taste and pungent in vipAka in association with rUkshatva (dryness) & hot potency – bAkuci expels and ameliorates kapha doSha.
    At the same time, the hot potency is capable of increasing the pitta doSha and reducing vAta doSha. The sara guna of pitta gets increased by regular intalke of bAkucI, there by resulting in sramsanam action causing elimination of pitta from the physical matrix, clinically speaking. The same sara guNa of the psoaralia altercates the viShTambha (obstruction) with in the pittavahana channels.Hence therapeutically as an Ayurveda physician, it gets used in clinical condition , of the diseases indicated for bAkucI observed in a patient – based on the following doshic equation pathologically,
    KV-vrddhi_ P- kshaya doshic equation,-as is seen in the clinical variations / varieties of of the following diseases –
    Hrdroga
    ShvAsa
    KuShTHa
    Jvara
    Krmi
    Shotha
    pANDuIt nourishes the integumentary system and protect the hairs (केष्यं) from kapha obstructing the keshamUla, along with providng shining to the skin (त्वच्यं).
  1. कफवातनुत् अवल्गुज: एडगज: || च.सू.२७/३३ ||
    Transliteration:-
    (kaphavātanut avalguja: eḍagaja: || ca.sū.27/33)

    Charaka too states,KV-vrddhi_ P- kshaya doshic equationto be the pharmacodynamics of the seeds of the avalguja, upon the doshic matrix.बाकुची is capable of providing pigmentation in leucoderma patches. The usual method adviced in the classical texts regarding the usage of bAkuchI is – after subjecting the rugna (patient) to raktavisrAvana (blood letting therapy) and there by letting the vitiated doshAs from the shAkAdaya dhAtus (local dhAtus like rasa, rakta & mAmsa), the bAkucIbIja kaShAya with guDa as anupAna be given. Else the bAkucI tailam with honey  be given for pAnArtham. And later bAkuci with dhAtri & khadira sAra in the proportions mentioned as in the classical texts related to pharmacology (bhaisajya kalapanA shAstra) be given daily as a regular dosage.When the sphotAs (vesicles) gets manifested as the clinical effect of using the bAkuci in afore said forms of yogAs, it should started to be given along with takra sans salt, and rice mixed with takra (butter milk) without adding lavan (sans salt) be partaken as regular diet, until the whitish patches gets vanished and fresh pigmentation covers the entire lesion of leucoderma or vitiligo.Its is at this stage of occurence of blisters, the patients usually stop following the medication out of fear of having got some side effect of the medicine. But, in actual it is the therapeutic effect of the medicine which gets induced upon taking the bAkuci seeds, caused by the increse in the prAkrta pitta seated within the layers of the skin.The tikta and katu predominance in the psoralia seeds reduces the excessive kleda amsha (pathological moistness) by drying it, counteracts the the kustha (obstinate skin diseases) and the krmis (which usually enjoy thriving and reproducing in moist and dampness in affected portions of the human body). In addition it instigates the secretion of normal pitta underneath the skin. It is for these pharmacodynamics (Ayurvedically) of the bAkuci, it is being considered as RasAyana by many of the well experienced vaidyas, who rely up on it for treating kuStha, gambhIradhAtu gata KuSThAs (deep seated skin diseases, means whose pathology starts at the level of the dermis).When it is adviced as a nitya rasayana, the following mediums gets adviced to mix the bAkuci churna,  depending upon the dosha, desha and season – milk, ghee, butter, honey. Which ever of the above medium be selected, upon considering the required Ayurvedic clinical parameters, buttermilk and the rice with buttermilk sans salt is to be followed as pathyA (required dietetic formula).In dadru, gajakarNa, pAmA, sidhma etc skin manifestations bAkucibIja chUran mixed with takra is adviced as lepanam. In case the vesicles erupt, after it gets burst open, the normal hue of the skin gets manifestedSome Common useful Yogas of bAkucI :-bākucī cūrṇa
    bākucī kvātha
    śaśilekhā vaṭi
    bākucī tailaṃ
    candraprabhā vaṭi
    mahā nīla tailaṃ (ca.ci.26/) -The mahāgandha hasti nāma agada (ca.ci.23/80) – this agada contains 60 ingredients of which bAkucI too is one. Vaidyas practicing toxicology rely up on this yoga.|| Charaka advices the to chant the following mantra before administering this agada indicated as a life saving emergency medicine in viSha chikitsA.Mantra in Agada treatment:-
    ‘मम माता जया नाम जयो नामेति मे पिता||९०||
    सोऽहं जयजयापुत्रो विजयोऽथ जयामि च|
    नमः पुरुषसिंहाय विष्णवे विश्वकर्मणे||९१||
    सनातनाय कृष्णाय भवाय विभवाय च|
    तेजो वृषाकपेः साक्षात्तेजो ब्रह्मेन्द्रयोर्यमे||९२||
    यथाऽहं नाभिजानामि वासुदेवपराजयम्|
    मातुश्च पाणिग्रहणं समुद्रस्य च शोषणम्||९३||
    अनेन सत्यवाक्येन सिध्यतामगदो ह्ययम्|
    हिलिमिलिसंस्पृष्टे रक्ष सर्वभेषजोत्तमे स्वाहाTransliteration of above mantra:-
    ‘mama mātā jayā nāma jayo nāmeti me pitā||90||
    so’haṃ jayajayāputro vijayo’tha jayāmi ca|
    namaḥ puruṣasiṃhāya viṣṇave viśvakarmaṇe||91||
    sanātanāya kṛṣṇāya bhavāya vibhavāya ca|
    tejo vṛṣākapeḥ sākṣāttejo brahmendrayoryame||92||
    yathā’haṃ nābhijānāmi vāsudevaparājayam|
    mātuśca pāṇigrahaṇaṃ samudrasya ca śoṣaṇam||93||
    anena satyavākyena sidhyatāmagado hyayam|
    hilimilisaṃspṛṣṭe rakṣa sarvabheṣajottame svāhāPrecautions:-
    Use with caution in pregnancy.

    Excessive UV therapy causes high pitta. [i]

    It is not given to patients suffering from liver diseases, lupus erythematosus, hydroaporphyria, or other diseases associated with light sensitivity.

    It is advised to avoid spicy diet, salt, and late nights during bakuchi regimen.

    Milk, ghee, and butter should be consumed in the diet.[ii]

    Seed oil should be avoided on eyes, and it should be mixed with coconut oil before application, because it is thermogenic.

    References:-
    [i] Sebastian P. Vol. 2. New York: Elsevier Health Sciences; 2006. Ayurvedic Medicine: The Principles of Traditional Practice; pp. 135–6.
    [ii] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249905/

    Research Studies on Bakuci:-

    1. The furanocoumarins, which contain psoralens, promote pigmentation[i]
    2. It also alleviates boils and skin eruptions. The plant has blood purifying properties. It is used to treat itching red papules, itching eruptions, extensive eczema with thickened dermis, ringworm, rough and discolored dermatosis, dermatosis with fissures, and scabies[ii]
    3. Seeds are given in scorpion-sting and snake bite[iii]
    4. The major components psoralen and isopsoralen have antitumor, antibacterial, and antiviral properties[iv]
    5. It shows coronary vasodilatory activity[v]
    6. The seeds act as deobstruent and heal ulcer, heart troubles, and cure blood disorders and elephantitis[vi]
    7. The herb is cytotoxic, antimutagenic, and antirepellant[vii]
    8. Katsura et al proved that bakuchiol is a useful compound against oral pathogens and has a great potential for use in food additives and mouthwashes for preventing and treating dental caries. The cell growth of mutans was inhibited in a bakuchiol concentration-dependent manner and the growth of S. mutans was completely prevented with 20 μg of bakuchiol/mL.[viii]
    9. Bakuchiol, one of the major constituent of corylifolia, has been shown to possess a prominent cytotoxic effect on L929 cells in all cultures. It also showed cytotoxicity against cultured human cell lines, namely, A549, SK-OV-3, SK-MEL-2, XF-498, and HCT-15.[ix]
    10. The water-soluble extract containing bakuchiol has been found to possess hepatoprotective activity in tacrine-induced cytotoxicity in human liver-derived HepG2 cells. The EC50 value of bakuchiol was 1 μg/mL and of silymarin was 5 μg/mL[x]
    11. The alcoholic extract produced death of microfilariae and showed antimycobacterial activity[xi]
    12. It was observed that flavonoids, mainly corylin and bavachin, have osteoblastic proliferation-stimulating activity and thus might stimulate bone formation and act against osteoporosis.[xii]
    13. Chandhoke and Ray reported that isopsoralen showed tranquillosedative, anticonvulsant, and central muscle-relaxant properties in rats, mice, and rabbits.[xiii]
    References:-
    [i] Sebastian P. Vol. 2. New York: Elsevier Health Sciences; 2006. Ayurvedic Medicine: The Principles of Traditional Practice; pp. 135–6.
    [ii] Khare CP. New York: Springer-Verlag; 2004. Encyclopedia of Indian Medicinal Plants; pp. 384–6.
    [iii] Nadkarni KM. Vol. 1. Mumbai: Popular Prakashan Pvt. Ltd; 1976. Indian Materia Medica; pp. 1019–22.
    [iv] Liu R, Li A, Sun A, Kong L. Preparative isolation and purification of psoralen and isopsoralen from Psoralea corylifolia by high-speed counter-current chromatography. J Chromatogr A. 2004;1057:225–8.
    [v] Ruan B, Kong LY, Takaya Y, Niwa M. Studies on chemical constituents of Psoralea corylifolia L. J Asian Nat Prod Res. 2007;9:
    [vi] Khatune NA, Islam ME, Rahman MA, Baki MA, Sadik G, Haque MA. Pesticidal activity of a novel coumestan derivative isolated from Psoralea corylifolia L. against Tribolium castaneum Herbst. adults and larvae. Pak J Agron. 2002;1:112–5
    [vii] Sah P, Agrawal D, Garg SP. Isolation and identification of furocoumarins from the seeds of Psoralea corylifolia L. Indian J Pharma Sci. 2006;68:768–71
    [viii] Katsura H, Tsukiyama RI, Suzuki A, Kobayashi M. In vitro antimicrobial activities of bakuchiol against oral microorganisms. Antimicrob Agents Chemother. 2001;45:3009–13.
    [ix] Rastogi RP, Mehrotra BN. Vol. 5. Lucknow, CDRI and New Delhi: NISCIR; 1998. Compendium of Indian Medicinal Plants; pp. 703–4.
    [x] Rajpal V. Vol. 2. New Delhi: Eastern Publishers; 2005. Standardization of Botanicals; pp. 284–95.
    [xi] Gupta AK, Neeraj T, Madhu S. Vol. 3. New Delhi: ICMR; 2005. Quality Standards of Indian Medicinal Plants; pp. 290–8.
    [xii] Rajpal V. Vol. 2. New Delhi: Eastern Publishers; 2005. Standardization of Botanicals; pp. 284–95
    [xiii] Kapoor LD. Boca Raton, Florida: CRC Press; 2001. Handbook of Ayurvedic Medicinal Plants; pp. 274–5.


     








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